APPENDIX II-F: Combined Exposures to Pesticides Containing Permethrin and DEET not recommended.
Too many of the recommendations
for use of DEET ignore the fact that
many people are simultaneously exposed to pesticides containing
permethrin -- which are used widely. This combination has been shown
to have potent synergistic effects. See paper below. A. Hotz
*****************************************
Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin:
Pharmacokinetics and toxicological effects
Abu-Qare AW, Abou-Donia MB
JOURNAL OF TOXICOLOGY AND
ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
6 (1): 41-53 2002
Addresses: Abu-Qare AW, Duke Univ, Med Ctr, Dept Pharmacol & Canc
Biol,
Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA
Document type: Review Language: English Cited References: 80
Times Cited: 0
Abstract: Permethrin and DEET are concurrently used for pests control
inside homes, in public places, and in military shelters. Combined
exposure to these compounds produced greater biochemical, behavioral,
and metabolic alterations in animals compared to each individual
compound. Concurrent application of DEET and permethrin induced
urinary
excretion of 3-nitrotyrosine and 8-hydroxy-2'-deoxyguanosine, markers
of
DNA damage and oxidative stress in rats, increased the release of rat
brain mitochondrial cytochrome c, disrupted the blood brain barrier
(BBB) in rats, decreased m2 muscarinic acetylcholine receptor ligand
binding density in rat brain, increased urinary excretion of
6beta-hydroxycortisol, a marker CYP3A4 induction, altered sensorimotor
and locomotor activities in rats, and changed in vivo and in vitro
metabolism and pharmacokinetic profiles of the individual compound.
These findings show that more research is needed to examine adverse
effects of the combined use of DEET and permethrin on other
biochemical/physiological system(s) and to predict mechanistic
pathways
for these effects, particularly mechanism of action at cellular and
molecular levels and alterations of genes transcription.
KeyWords Plus:
INSECT REPELLENT N,N-DIETHYL-M-TOLUAMIDE, PERFORMANCE
LIQUID-CHROMATOGRAPHY, ALTER LOCOMOTOR BEHAVIOR, SOLID-PHASE
EXTRACTION,
DIETHYL-M-TOLUAMIDE, GULF-WAR SYNDROME, PYRIDOSTIGMINE BROMIDE,
PYRETHROID INSECTICIDES, RAT PLASMA, SENSORIMOTOR PERFORMANCE
Publisher: TAYLOR & FRANCIS INC, PHILADELPHIA IDS Number: 616YV ISSN:
1093-7404
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Received on Thu Mar 20 14:15:27 2003
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