APPENDIX II-G: Permethrin and Breast Cancer Studies.

 

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Pyrethroids and Breast Cancer Risk
Bibliography

This bibliography is provided as a service to our readers. It is compiled from the entries in the BCERF Environmental Risk Factors Bibliographic Database.

This bibliography is arranged topically. The topics include:


Review Articles

Carter, S. W. (1989). A review of the use of synthetic pyrethroids in public health and vector pest control. Pesticide Science 27, 361-374.

Casida, J. E. (1980). Pyrethrum flowers and pyrethroid insecticides. Environmental Health Perspectives 34, 189-202.

Casida, J. E., and Ruzo, L. O. (1980). Metabolic chemistry of pyrethroid insecticides. Pesticide Science 11, 257-269.

He, F. (1994). Chapter 6, Synthetic pyrethroids. Toxicology 91, 43-49.

IARC. (1991). Permethrin. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Occupational Exposures in Insecticide Application, and Some Pesticides, vol. 53 (Lyon, France: International Agency for Research on Cancer; World Health Organization), pp. 329-349.

Katsuda, Y. (1999). Development of and future prospects for pyrethroid chemistry. Pesticide Science 55, 775-782.

Litchfield, M. (1983). Characterization of the principal mammalian toxicological and biological actions of synthetic pyrethroids. In Pesticide Chemistry: Human Welfare and the Environment, J. Miyamoto, ed. (Oxford, England: Pergamon Press), pp. 207-211.

Litchfield, M. H. (1985). Toxicity to mammals. In The Pyrethroid Insecticides, J. P. Leahy, ed. (London: Taylor & Francis), pp. 99-141.

Miyamoto, J. (1976). Degradation, metabolism and toxicity of synthetic pyrethroids. Environmental Health Perspectives 14, 15-28.

Otieno, D. A., and Pattenden, G. (1980). Degradation of the natural pyrethroids. Pesticide Science 11, 270-278.

Pap, L., Bajomi, D., and Szekely, I. (1996). The pyrethroids, an overview. International Pest Control 38, 15-19.

WHO. (1989). Environmental Health Criteria 92; Resmethrins-Resmethrin Bioresmethrin Cisresmethrin (Geneva: World Health Organization), pp. 1-73.

WHO. (1990). Environmental Health Criteria 94; Permethrin (Geneva: World Health Organization), pp. 1-114.

WHO. (1990). Environmental Health Criteria 96; d-Phenothrin (Geneva: World Health Organization).

Cancer Risks of Pyrethroids

Brown, L. M., Blair, A., Gibson, R., Everett, G. D., Cantor, K. P., Schumann, L. M., Burmeister, L. F., Van Lier, S. F., and Dick, F. (1990). Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research 50, 6585-6591.

Burmeister, L. F. (1990). Cancer in Iowa farmers: Recent results. American Journal of Industrial Medicine 18, 295-301.

Butler, W. H., Cohen, S. H., and Squire, R. A. (1997). Mesenchymal tumors of the mouse urinary bladder with vascular and smooth muscle differentiation. Toxicologic Pathology 25, 268-274.

Cabral, J. R. P., and Galendo, D. (1990). Carcinogenicity study of the pesticide fenvalerate in mice. Cancer Letters 49, 13-18.

Cabral, J. R. P., Galendo, D., Laval, M., and Lyandrat, N. (1990). Carcinogenicity studies with deltamethrin in mice and rats. Cancer Letters 49, 147-152.

Gold, L. S., Stern, B. R., Slone, T. H., Brown, J. P., Manley, N. B., and Ames, B. N. (1997). Pesticide residues in food: investigation of disparities in cancer risk estimates. Cancer Letters 117, 195-207.

Hagiwara, A., Yamada, M., Hasegawa, R., Fukushima, S., and Ito, N. (1990). Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats. Cancer Letters 54, 67-73.

Hakoi, K., Cabral, R., Hoshiya, T., Hasegawa, R., Shirai, T., and Ito, N. (1992). Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat. Teratogenesis, Carcinogenesis, and Mutagenesis 12, 269-276.

Hemming, H., Flodstrom, S., and Warngard, L. (1993). Enhancement of altered hepatic foci in rat liver and inhibition of intercellular communication in vitro by the pyrethroid insecticides fenvalerate, flucythrinate and cypermethrin. Carcinogenesis 14, 2531-2535.

Ishmael, J., and Litchfield, M. H. (1988). Chronic toxicity and carcinogenic evaluation of permethrin in rats and mice. Fundamental and Applied Toxicology 11, 308-322.

Kostka, G., Palut, D., Kopec-Szlezak, J., and Ludwicki, J. K. (2000). Early hepatic changes in rats induced by permethrin in comparison with DDT. Toxicology 142, 135-143.

Litchfield, M. H. (1985). Toxicity to mammals. In The Pyrethroid Insecticides, J. P. Leahy, ed. (London: Taylor & Francis), pp. 99-141.

Miyamoto, J. (1976). Degradation, metabolism and toxicity of synthetic pyrethroids. Environmental Health Perspectives 14, 15-28.

Parker, C. M., McCullough, C. B., Gallatly, J. B. M., and Johnston, C. D. (1983). Toxicologic and carcinogenic evaluation of fenvalerate in the B6C3F1 mouse. Fundamental and Applied Toxicology 3, 114-120.

Parker, C. M., Patterson, D. R., and Van Gelder, G. A. (1984). Chronic toxicity and carcinogenicity evaluation of fenvalerate in rats. Journal of Toxicology and Environmental Health 13, 83-97.

Pogoda, J. M., and Preston-Martin, S. (1997). Household pesticides and risk of pediatric brain tumors. Environmental Health Perspectives 105, 1214-1220.

Genotoxicity Studies

Barrueco, C., Herrera, A., Caballo, C., and de la Pe–a, E. (1992). Cytogenetic effects of permethrin in cultured human lymphocytes. Mutagenesis 7, 433-437.

Barrueco, C., Herrera, A., Caballo, C., and de la Pe–a, E. (1994). Induction of structural chromosome aberrations in human lymphocyte cultures and CHO cells by permethrin. Teratogenesis, Carcinogenesis, and Mutagenesis 14, 31-38.

Bartsch, H., Malaveille, C., Camus, A. M., Martel-Planche, G., Brun, G., Hautefeuille, A., Sabadie, N., Barbin, A., Kuroki, T., Drevon, C., Piccoli, C., and Montesano, R. (1980). Validation and comparative studies of 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems. Mutation Research 76, 1-50.

Bhunya, S. P., and Pati, P. C. (1990). Effect of deltamethrin, a synthetic pyrethroid, on the induction of chromosome aberrations, micronuclei and sperm abnormalities. Mutagenesis 5, 229-232.

Bhunya, S. P., and Pati, P. C. (1988). Genotoxic effects of a synthetic pyrethroid insecticide, cypermethrin, in mice in vivo. Toxicology Letters 41, 223-230.

Caballo, C., Herrera, A., Carrueco, C., Santa-Maria, A., Sanz, F., and de la Pe–a, E. (1992). Analysis of cytogenetic damage induced in CHO cells by the pyrethroid insecticide fenvalerate. Teratogenesis, Carcinogenesis, and Mutagenesis 12, 243-249.

Hemming, H., Flodstrom, S., and Warngard, L. (1993). Enhancement of altered hepatic foci in rat liver and inhibition of intercellular communication in vitro by the pyrethroid insecticides fenvalerate, flucythrinate and cypermethrin. Carcinogenesis 14, 2531-2535.

Herrera, A., and Laborda, E. (1988). Mutagenic activity in synthetic pyrethroids in Salmonella typhimurium. Mutagenesis 3, 509-514.

Hoellinger, H., Lecorsier, A., Sonnier, M., Leger, C., Thang, D. C., and Nam, N. H. (1987). Cytotoxicity, cytogenotoxicity and allergenicity tests on certain pyrethroids. Drug and Chemical Toxicology 10, 291-310.

Hour, T., Chen, L., and Lin, J. (1998). Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests. Mutagenesis 13, 157-166.

Instit—ris, L., Undeger, U., Siroki, O., NehŽz, M., and DŽsi, I. (1999). Comparison of detection sensitivity of immuno- and genotoxicological effects of subacute cypermethrin and permethrin exposure in rats. Toxicology 137, 47-55.

Johnson, B. (1992). An evaluation of a genotoxicity assay with liver S9 for activation and luminescent bacteria for detection. Environmental Toxicology and Chemistry 11, 473-480.

Kornuta, N., Bagley, E., and Nedopitanskaya, N. (1996). Genotoxic effects of pesticides. Journal of Environmental Pathology, Toxicology and Oncology 15, 75-78.

Kostka, G., Palut, D., Kopec-Szlezak, J., and Ludwicki, J. K. (2000). Early hepatic changes in rats induced by permethrin in comparison with DDT. Toxicology 142, 135-143.

Lander, F., and Ronne, M. (1995). Frequency of sister chromatid exchanges and hematological effects in pesticide-exposed greenhouse sprayers. Scandinavian Journal of Work, Environment and Health 21, 283-288.

Litchfield, M. H. (1985). Toxicity to mammals. In The Pyrethroid Insecticides, J. P. Leahy, ed. (London: Taylor & Francis), pp. 99-141.

Miyamoto, J. (1976). Degradation, metabolism and toxicity of synthetic pyrethroids. Environmental Health Perspectives 14, 15-28.

Moriya, M., Ohta, T., Watanabe, K., Miyazawa, T., Kato, K., and Shirasu, Y. (1983). Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutation Research 116, 185-216.

Pednekar, M. D., Gandhi, S. R., and Netrawali, M. S. (1987). Evaluation of mutagenic activities of endosulfan, phosalone, malathion, and permethrin, before and after metabolic activation, in the Ames Salmonella test. Bulletin of Environmental Contamination and Toxicology 38, 925-933.

Pluijmen, M., Drevon, C., Montesano, R., Malaveille, C., Hautefeuille, A., and Bartsch, H. (1984). Lack of mutagenicity of synthetic pyrethroids in Salmonella typhimurium strains and in V79 chinese hamster cells. Mutation Research 137, 7-15.

Rupa, D., Reddy, P., and Reddi, O. (1989). Chromosomal aberrations in peripheral lymphocytes of cotton field workers exposed to pesticides. Environmental Research 49, 1-6.

Rupa, D., Reddy, P., and Reddi, O. (1991). Clastogenic effect of pesticides in peripheral lymphocytes of cotton-field workers. Mutation Research 261, 177-180.

SurrallŽs, J., Xamena, N., Creus, A., Catal‡n, J., Norppa, H., and Marcos, R. (1995). Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures. Mutation Research 341, 169-184.

Villarini, M., Moretti, M., Pasquini, R., Scassellati-Sforzolini, G., Fatigoni, C., Marcarelli, M., Monarca, S., and Rodriquez, A. V. (1998). In vitro genotoxic effects of the insecticide deltamethrin in human peripheral blood leukocytes: DNA damage ('comet' assay) in relation to the induction of sister-chromatid exchanges and micronuclei. Toxicology 130, 129-139.

Immunotoxicity Studies

Blaylock, B. L., Abdel-Nassar, M., McCarty, S. M., Knesel, J. A., Tolson, K. M., Ferguson, P. W., and Mehendale, H. M. (1995). Suppression of cellular immune responses in BALB/c mice following oral exposure to permethrin. Bulletin of Environmental Contamination and Toxicology 54, 768-774.

DŽsi, I., Dobronyi, I., and Varga, L. (1986). Immuno-, neuro-, and general toxicologic animal studies on a synthetic pyrethroid: cypermethrin. Ecotoxicology and Environmental Safety 12, 220-232.

Diel, F., Horr, B., Borck, H., Savtchenko, H., Mitsche, T., and Diel, E. (1999). Pyrethroids and piperonyl-butoxide affect human T-lymphocytes in vitro. Toxicology Letters 107, 65-74.

Hoellinger, H., Lecorsier, A., Sonnier, M., Leger, C., Thang, D. C., and Nam, N. H. (1987). Cytotoxicity, cytogenotoxicity and allergenicity tests on certain pyrethroids. Drug and Chemical Toxicology 10, 291-310.

Instit—ris, L., Undeger, U., Siroki, O., NehŽz, M., and DŽsi, I. (1999). Comparison of detection sensitivity of immuno- and genotoxicological effects of subacute cypermethrin and permethrin exposure in rats. Toxicology 137, 47-55.

Madsen, C., Claesson, M. H., and Ršpke, C. (1996). Immunotoxicity of the pyrethroid insecticides deltamethrin and alpha-cypermethrin. Toxicology 107, 219-227.

Santoni, G., Cantalamessa, F., Mazzucca, L., Romagnoli, S., and Piccoli, M. (1997). Prenatal exposure to cypermethrin modulates rat NK cell cytotoxic functions. Toxicology 120, 231-242.

Endocrine Disruption Studies

Akhtar, N., Kayani, S. A., Ahmad, M. M., and Shahab, M. (1996). Insecticide-induced changes in secretory activity of the thyroid gland in rats. Journal of Applied Toxicology 16, 397-400.

da Silva Gomes, M., Bernardi, M. M., and de Souza Spinosa, H. (1991). Pyrethroid insecticides and pregnancy: effect on physical and behavioral development of rats. Veterinary and Human Toxicology 33, 315-317.

Eil, C., and Nisula, B. C. (1990). The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin. Journal of Steroid Biochemistry 35, 409-414.

Garey, J., and Wolff, M. S. (1998). Estrogenic and antiprogestagenic activities of pyrethroid insecticides. Biochemical and Biophysical Research Communications 251, 855-859.

Go, V., Garey, J., Wolff, M. S., and Pogo, B. G. T. (1999). Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast cancer cell line. Environmental Health Perspectives 107, 173-177.

Kaul, P. P., Rastogi, A., Hans, R. K., Seth, T. D., Seth, P. K., and Srimal, R. C. (1996). Fenvalerate-induced alterations in circulatory thryoid hormones and calcium stores in rat brain. Toxicology Letters 89, 29-33.

Moniz, A. C., Cruz-Casallas, P. E., Oliviera, C. A., Lucisano, A., Florio, J. C., Nicolau, A. A., Spinosa, H. S., and Bernardi, M. M. (1999). Perinatal fenvalerate exposure: behavioral and endocrinology changes in male rats. Neurotoxicology and Teratology 21, 611-618.

Tchernitchin, A., Tchernitchin, N., Mena, M., Unda, C., and Soto, J. (1999). Imprinting: perinatal exposures cause the development of diseases during the adult age. Acta Biologica Hungarica 50, 425-440.

Exposure to Pyrethroids:

Oral Exposure and Residues on Food

Bissacot, D. Z., and Vassileff, I. (1997). Pyrethroid residues in milk and blood of dairy cows following single topical applications. Veterinary and Human Toxicology 39, 6-8.

FDA. (1999). Food and Drug Administration Total Diet Study; summary of residues found ordered by pesticide, market baskets 91-3-97-1, June 1999 (U.S. Food and Drug Administration: Available: http://vm.cfsan.fda.gov/~acrobat/TDS1byps.pdf [cited June, 2000]).

Gaughan, L. C., Ackerman, M. E., Unai, t., and Casida, J. E. (1978). Distribution and metabolism of trans- and cis-Permethrin in lactating Jersey cows. Journal of Agricultural and Food Chemistry 26, 613-618.

Gold, L. S., Stern, B. R., Slone, T. H., Brown, J. P., Manley, N. B., and Ames, B. N. (1997). Pesticide residues in food: investigation of disparities in cancer risk estimates. Cancer Letters 117, 195-207.

IARC. (1991). Permethrin. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Occupational Exposures in Insecticide Application, and Some Pesticides, vol. 53 (Lyon, France: International Agency for Research on Cancer; World Health Organization), pp. 329-349.

Nakamura, Y., Tonogai, Y., Tsumura, Y., and Ito, Y. (1993). Determination of pyrethroid residues in vegetables, fruits, grains, beans, and green tea leaves: applications to pyrethroid residue monitoring studies. Journal Association of Official Analytical Chemists International 76, 1348-1361.

Ridlen, R. L., Christopher, R. J., Ivie, G. W., Beier, R. C., and Camp, B. J. (1984). Distribution and metabolism of cis- and trans-Resmethrin in lactating jersey cows. Journal of Agricultural and Food Chemistry 32, 1211-1217.

Travis, C. C., and Arms, A. D. (1988). Bioconcentration of organics in beef, milk, and vegetation. Environmental Science and Technology 22, 271-274.

Yess, N. J., Gunderson, E. L., and Roy, R. R. (1993). U.S. Food and Drug Administration monitoring of pesticide residues in infant foods and adult foods eaten by infants/children. Journal of AOAC International 76, 492-507.

Occupational Exposure

Asakawa, F., Jitsunari, F., Miki, K., Choi, J.-O., Takeda, N., Kitamado, T., Suna, S., and Manabe, Y. (1996). Agricultural worker exposure to and absorption of permethrin applied to cabbage. Bulletin of Environmental Contamination and Toxicology 56, 42-49.

Brown, L. M., Blair, A., Gibson, R., Everett, G. D., Cantor, K. P., Schumann, L. M., Burmeister, L. F., Van Lier, S. F., and Dick, F. (1990). Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research 50, 6585-6591.

Burmeister, L. F. (1990). Cancer in Iowa farmers: Recent results. American Journal of Industrial Medicine 18, 295-301.

Carter, S. W. (1989). A review of the use of synthetic pyrethroids in public health and vector pest control. Pesticide Science 27, 361-374.

Flannigan, S. A., Tucker, S. B., Key, M. M., Ross, C. E., Fairchild, E. J., II., Grimes, B. A., and Harrist, R. B. (1985). Synthetic pyrethroid insecticides: a dermatological evaluation. British Journal of Industrial Medicine 42, 363-372.

He, F. (1994). Synthetic pyrethroids. Toxicology 91, 43-49.

IARC. (1991). Permethrin. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Occupational Exposures in Insecticide Application, and Some Pesticides (Lyon, France: International Agency for Research on Cancer; World Health Organization), pp. 329-349.

Kolmodin-Hedman, B., Akerblom, M., Flato, S., and Alex, G. (1995). Symptoms in forestry workers handling conifer plants treated with permethrin. Bulletin of Environmental Contamination and Toxicology 55, 487-493.

Household Exposure

IARC. (1991). Permethrin. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Occupational Exposures in Insecticide Application, and Some Pesticides, vol. 53 (Lyon, France: International Agency for Research on Cancer; World Health Organization), pp. 329-349.

Knepper, R. G., Walker, E. D., Wagner, S. A., Kamrin, M. A., and Zabik, M. J. (1996). Deposition of malathion and permethrin on sod grass after single, ultra-low volume applications in a suburban neighborhood in Michigan. Journal of the American Mosquito Control Association 12, 45-51.

Leiss, J. K., and Savitz, D. A. (1995). Home pesticide use and childhood cancer: A case-control study. American Journal of Public Health [abstract] 85, 249-252.

Lewis, R. G., Fortune, C. R., Willis, R. D., Camann, D. E., and Antley, J. T. (1999). Distribution of pesticides and polycyclic aromatic hydrocarbons in house dust as a function of particle size. Environmental Health Perspectives 107, 721-726.

Matoba, Y., Takimoto, Y., and Kato, T. (1998). Indoor behavior and risk assessment following residual spraying of d-phenothrin and d-tetramethrin. American Industrial Hygiene Association Journal 59, 191-199.

Matoba, Y., Takimoto, Y., and Kato, T. (1998). Indoor behavior and risk assessment following space spraying of d-tetramethrin and d-resmethrin. American Industrial Hygiene Association Journal 59, 181-190.

Pauluhn, J. (1996). Risk assessment of pyrethroids following indoor use. Toxicology Letters 88, 339-348.

Roinestad, K. S., Louis, J. B., and Rosen, J. D. (1993). Determination of pesticides in indoor air and dust. Journal of AOAC International 76, 1121-1126.

Waliszewski, S. M., Aguirre, A. A., Infanz—n, R. M., Rivera, J., and Infanz—n, R. (1998). Time trend of organochlorine pesticide residues in human adipose tissue in Veracruz, Mexico: 1988-1997 survey. The Science of the Total Environment 221, 201-204.

Environmental Fate

Carter, S. W. (1989). A review of the use of synthetic pyrethroids in public health and vector pest control. Pesticide Science 27, 361-374.

IARC. (1991). Permethrin. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Occupational Exposures in Insecticide Application, and Some Pesticides (Lyon, France: International Agency for Research on Cancer; World Health Organization), pp. 329-349.

Katsuda, Y. (1999). Development of and future prospects for pyrethroid chemistry. Pesticide Science 55, 775-782.

Knepper, R. G., Walker, E. D., Wagner, S. A., Kamrin, M. A., and Zabik, M. J. (1996). Deposition of malathion and permethrin on sod grass after single, ultra-low volume applications in a suburban neighborhood in Michigan. Journal of the American Mosquito Control Association 12, 45-51.

Leahy, J. P. (1985). Metabolism and environmental degradation. In The Pyrethroid Insecticides, J. P. Leahy, ed. (London: Taylor and Francis), pp. 263-326.

Miyamoto, J. (1976). Degradation, metabolism and toxicity of synthetic pyrethroids. Environmental Health Perspectives 14, 15-28.

Otieno, D. A., and Pattenden, G. (1980). Degradation of the natural pyrethroids. Pesticide Science 11, 270-278.

Pap, L., Bajomi, D., and Szekely, I. (1996). The pyrethroids, an overview. International Pest Control 38, 15-19.

Ueda, K., Gaughan, L. C., and Casida, J. E. (1974). Photodecomposition of resmethrin and related pyrethroids. Journal of Agricultural and Food Chemistry 22, 212-220.

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Prepared 9.7.00 by Michael J. Marshall, Independent Study Student,
under the supervision of Suzanne M. Snedeker, Ph.D.

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